“We now plan to delve deeper into the underlying mechanisms of infections in individuals with diabetes,” said the study’s lead author Soumitra Mohanty, a researcher at the same division of Karolinska Institutet. “The ultimate goal is to reduce the risk of infection in this growing patient population.”
The study was conducted in collaboration with Karolinska University Hospital, Region Stockholm, Capio and Uppsala University in Sweden and Universitätsklinikum Schleswig-Holstein in Germany. It was largely funded by the Olle Engkvist Foundation, Region Stockholm (ALF funding), the KI Research Foundation, the Swedish Society of Medicine, the Swedish Society for Medical Research (SSMF), the Clas Groschinsky Memorial Foundation, the Åke Wiberg Foundation and the Magnus Bergvall Foundation. There are no reported conflicts of interest.
“Diabetes upregulates the antimicrobial peptide psoriasin and increases the E. coli burden in the urinary bladder”. Soumitra Mohanty, Witchuda Kamolvit, Andrea Scheffschick, Anneli Björklund, Jonas Tovi, Alexander Espinosa, Kerstin Brismar, Thomas Nyström, Jens M. Schröder, Claes-Göran Östenson, Pontus Aspenström, Hanna Brauner, Annelie Brauner. Nature Communications, online Sept. 20, 2022, doi: 10.1038/s41467-022-32636-y.