College football picks, schedule: predictions against the spread, odds for top 25 games in week 5

With a third of the 2022 season on the books and college football rankings more normalized across the board, Week 5 offers some great top-25 matchups with implications for individual conferences and the College Football Playoff picture. In fact, these clashes are spread across Saturday’s schedule, giving fans a chance to tune in to as many people as possible during the day.

In fact, there are five matches between ranked opponents on the day with two such matches between SEC and ACC opponents. No. 14 Ole Miss hosts No. 7 Kentucky as a touchdown favorite despite its higher ranking, while No. 2 Alabama takes the road at No. 20 Arkansas as a 17-point favorite, according to Caesars Sportsbook. No. 23 Florida State looks to go undefeated with a home run against No. 22 Wake Forest before No. 5 Clemson and No. 10 NC State meet as top-10 undefeated in a primetime showcase. Not to be missed, No. 16 Baylor is looking to jump back to the top of the Big 12 race when it hosts the undefeated No. 9 Oklahoma State.

By the time Saturday’s action ends, the top 25 will look significantly different, and there could even be significant changes in CFP forecasts. (While there are two games scheduled for Sunday with Sunshine State teams having to postpone their kick-off due to Hurricane Ian, neither contains ranked programs.)

Be sure to stick with CBS Sports all day for coverage of college football from kick-off. Let’s take a look at our expert picks for the best games in Week 5.

Opportunities through Caesars Sportsbook | All times Eastern

No. 4 Michigan in Iowa

Featured game | Iowa Hawkeyes vs. Michigan Wolverines

Afternoon | Fox, fuboTV (Try for free) — When these teams met in the Big Ten Championship Game last December, Michigan thoroughly defeated Iowa 42-3. The jury is out on whether the Wolverines are as good as last season, but Iowa appears to have gone downhill. Having scored just four offensive touchdowns in four games, the Hawkeyes now face an opponent far better than they’ve seen yet. Michigan gave up four touchdown drives of 70 yards or more in a 34-27 win over Maryland last week, but the Terrapins are much better equipped offensively than Iowa. Even if the Hawkeyes manage to slow down Michigan’s offense, it’s hard to see them reach double digits without some ridiculous turnover luck. The Wolverines should cover this spread with a 1920s score. Forecast: Michigan -10.5 — David Cobb

No. 7 Kentucky at No. 14 Ole Miss

Featured game | Ole Miss Rebels vs. Kentucky Wildcats

Afternoon | ESPN, fuboTV (Try for free) — The Rebels are heavy favorites entering the game despite a lower ranking. Don’t count the Wildcats, though. Kentucky has a big defensive advantage along with more experience in the quarterback position. Ole Miss’s offensive reputation under coach Lane Kiffin is well established, but Jaxson Dart has not been tested against a quality defence. That will change this week. Forecast: Kentucky +7 — Shehan Jeyarajah

no. 2 Alabama at No. 20 Arkansas

Featured game | Arkansas Razorbacks vs. Alabama Crimson Tide

3.30 pm | CBS, CBSSports.com, CBS Sports AppPart of the reason Alabama wasn’t good on the road is that the offensive line wasn’t up to the typical standard. This year’s offense in Alabama hasn’t been nearly as explosive in the passing game as we’ve seen in years past. There is no true alpha receiver – at least not one that has taken the reins from the excellent receivers Alabama had on its list. All that coupled with the fact that Arkansas fell into the cover, forcing teams to put together long rides to beat it, suggests this will be a lower-scoring, closer affair than expected. I don’t have much faith in it, but if I’m going to bet anything here, I’d rather be on the Razorbacks. Forecast: Arkansas +17 – Tom Fornell

no. 9 Oklahoma State at No. 16 Baylor

Featured game | Baylor Bears vs. Oklahoma State Cowboys

3.30 pm | Fox, fuboTV (Try for free) — Oklahoma State has won its last two regular-season games between these teams, but the Cowboys have not been tested in 2022 since the loss of defensive coordinator Jim Knowles to Ohio State. The Bears have maintained their impressive defensive performance and showed real advantage in the passing game in a win over Iowa State. Home advantage carries the day. Forecast: Baylor -2.5 — Shehan Jeyarajah

no. 10 NC State at No. 5 Clemson

Featured game | Clemson Tigers vs. NC State Wolfpack

7:30 pm | ESPN, fuboTV (Try for free) — I’ll take Clemson straight up but give me NC State grab points on the road. Clemson will win the battle in the line of scrimmage and force a few mistakes from Devin Leary that prevent this from turning into a shootout. Tigers turning back Will Shipley will take over late and avoid DJ Uiagalelei having to be a difference maker for the second week in a row. This one comes down to the final ride or two, and the Tigers will hold on to keep their hopes of the National Championship alive. Prediction: NC status +6.5 –Barrett Sallee

Which college football picks can you make with confidence in Week 5, and which top-10 favorite will go down hard? Visit SportsLine to see which teams will win and cover the spread – all based on a proven computer model that has brought in more than $3,100 in profits over the past six seasons – and find out.

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