College football picks, schedule: predictions against the spread, odds for top 25 games in week 4

With the arrival of the last weekend in September, the conference game around the college football landscape is getting underway. Week 4’s action on Saturday is packed with top 25 teams making their debut in the conference game for the 2022 season. That familiarity often comes with tighter games and tighter scores, as teams with more intimate knowledge of each other serve as a better litmus test. than the cannon fodder of non-conference game.

In total there will be three conference matches in which a pair of top 25 teams try to get an early position in the standings. There’s plenty to prove for the likes of No. 10 Arkansas, No. 11 Tennessee, and No. 21 Wake Forest who seek more respect within their respective division races against ranked conference opponents. In the Big Ten, No. 3 Ohio State and No. 4 Michigan will try to keep a strong start against teams they have dominated in recent years. The evening will conclude with a Big 12 battle between No. 6 Oklahoma and Kansas State in what has lately become a trap game for the Sooners.

Be sure to stick with CBS Sports all day for coverage of college football from kick-off. Let’s take a look at our expert picks for the best games in Week 4.

Opportunities through Caesars Sportsbook | All times Eastern

Featured game | Michigan Wolverines vs. Maryland Terrapins

Afternoon | Fox, fuboTV (Try for free) — The Terrapins will present a much greater challenge to Michigan than any previous opponent, especially in the field with their aggressive passing attack. However, the Wolverines are definitely cleaning up against some bad competition in their first three games. Many have been waiting for Michigan to make the switch to JJ McCarthy below center, so don’t be surprised to see the Wolverines also take a few more shots than usual. It may be a back door, but it will be a cover nonetheless. Prediction: Michigan -17 — Shehan Jeyarajah

Featured game | Wake Forest Demon Deacons vs. Clemson Tigers

Afternoon | ABC, fuboTV (Try for free) — Wake Forest has found outright success or at least more competitive results against every other ACC team except the Tigers, and the reason comes down to a major disadvantage in the scrimmage. Throughout the College Football Playoff era, we were blinded by some of the quarterbacks and wide receivers to get through Clemson, but the most consistent unit from year to year has been the defensive line. That defensive front has overwhelmed Wake Forest over the years, disrupting all the intricate and well-crafted aspects of the crime. I think that trend will continue, as will the trend of double digit wins. Prediction: Clemson -7 — Chip Patterson

Featured game | Tennessee Volunteers vs Florida Gators

3.30 pm | CBS,, CBS Sports AppFlorida has won 16 of the last 17 games in this series, and the Volunteers have won this game by more than 10 points only once in the past 30 years. History aside, Tennessee’s status as a double-digit favorite seems to overstate the win against a stumbling Pittsburgh team and underestimate Florida’s win over Utah. The Gators have been looking bad for the past two weeks, but there’s enough talent on the roster – as evidenced by that win over the Utes – to keep it close against a Vols program that is in its rebuilding rather than a No. 11 ranking might suggest. Forecast: Florida +10.5 — David Cobb

Featured game | Texas A&M Aggies vs. Arkansas Razorbacks

7 p.m. | ESPN, fuboTV (Try for free) — Give me the Razorbacks, and give me big. Raheim Sanders, the SEC’s leading rusher, was a specter between tackles and out in space. Along with KJ Jefferson, he will wear out this defensive front and leave late. On the other side of the ball, the brisk Hogs pass rush will exploit the struggling Aggies defense line, putting Max Johnson and the attack behind the sticks. That’s a recipe for disaster for Johnson and a passing game that hasn’t shown any sign of life yet. Forecast: Arkansas (+1.5) –Barrett Sallee

Featured game | Ohio State Buckeyes vs. Wisconsin Badgers

7:30 pm | ABC, fuboTV (Try for free) — While I have far too much respect for Wisconsin’s defensive coordinator Jim Leonhard to believe that the state of Ohio will do the kinds of things it has done to its last few opponents, I don’t have nearly the same level of confidence in the Wisconsin. attack to stay in this game. Until Graham Mertz proves to me that he can be trusted against top opponents, I’m not betting this is the case. Place the points with the Buckeyes. Prediction: Ohio State -18 – Tom Fornell

Featured game | Oklahoma Sooners vs. Kansas State Wildcats

8 p.m. | Fox, fuboTV (Try for free) — Kansas State has quietly played Oklahoma better than anyone since Chris Klieman took over the program in 2019. The Wildcats defeated OU each of Klieman’s first two seasons and played the Sooners within a score in 2021. There was optimism that this could be the best team of Klieman’s tenure, but an unexplained loss to Tulane put a damper on that. However, expect the Wildcats to keep the game within two scores. Prediction: Kansas State +13 — Shehan Jeyarajah

Which college football picks can you make with confidence in Week 4, and which Top 25 favorite will go down hard? Visit SportsLine to see which teams will win and cover the spread — all based on a tried-and-true computer model that’s brought in more than $3,300 in profits over the past six seasons — and find out.

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